Rationing antibiotic use in neonatal units

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Antibiotic use in the neonatal unit.

The changing pattern of organisms causing neonatal sepsis, from Streptococcus pyogenes in the 1930s to Staphylococcus aureus in the 1950s and more recently to Gram negative bacilli and the group B streptococcus,' has been reflected in the development of new antibiotics. In particular semi-synthetic penicillins and the so called third generation cephalosporins have been introduced, both with act...

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Antibiotic use in neonatal intensive care.

The Centers for Disease Control and Prevention estimates that .2 million people in the United States become ill every year due to antibiotic-resistant infections, and at least 23 000 die as a result. In India, newborn infants develop bacterial infections that are resistant to most known antibiotics; such infections led to the deaths of 58 000 infants in 2013. These problems seem distant to your...

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Neonatal intensive care unit antibiotic use.

BACKGROUND AND OBJECTIVES Treatment of suspected infection is a mainstay of the daily work in the NICU. We hypothesized that NICU antibiotic prescribing practice variation correlates with rates of proven infection, necrotizing enterocolitis (NEC), mortality, inborn admission, and with NICU surgical volume and average length of stay. METHODS In a retrospective cohort study of 52,061 infants in...

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Off-label use of drugs in neonatal intensive care units.

OBJECTIVE To estimate proportion of off-label medication use in neonates and to evaluate evidence of efficacy and safety of these medications. METHODS Chart audit in neonatal intensive care units of two institutions in Chandigarh, India. RESULTS Among 568 prescriptions in 156 neonates, 286 (50%) were off-label. Of these, 56% drugs were not approved for use in neonatal age group and 26% pres...

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Decreasing antibiotic overuse in neonatal intensive care units: quality improvement research.

Overutilization of antibiotics and emergence of resistant bacteria are important problems, particularly in intensive care units. To date, reproducible interventions to improve antibiotic utilization in hospitals have not been proven to be effective or safe. Evidence-based medicine, clinical practice guidelines, and health information technology are frequently promoted as means to cross the "qua...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood - Fetal and Neonatal Edition

سال: 2000

ISSN: 1359-2998,1468-2052

DOI: 10.1136/fn.82.1.f1